• Welcome to WindMIL
    A platform for cell-based immuno-oncology therapy

About

WHAT WINDMIL Therapeutics DOES

WindMIL is a clinical-stage biotechnology company developing a new class of cell therapy. Founders Ivan Borrello, MD, and Kimberly Noonan, PhD, from Johns Hopkins University (JHU) have shown that T cells capable of recognizing and killing tumor cells lie dormant in the bone marrow of cancer patients. These T cells, known as marrow-infiltrating lymphocytes (MILs), can be extracted from a patient via a routine marrow draw, activated and expanded utilizing a proprietary process, and given back to the patient as an effective and durable therapy. WindMIL has exclusively licensed from JHU the patents and know-how enabling MILs therapy.

Technology

WHAT MAKES MILS SPECIAL

MILs have several features that make them uniquely suited for cellular therapy of cancer. These include:

MILs possess specificity for a broad array of tumor antigens. This reduces the likelihood of tumor escape via the loss of any single antigen. It also obviates the need to identify a particular tumor-specific antigen to target—the body has already done this—leaving only those T cells specific for nonself present in the population of MILs.
Bone marrow is a natural reservoir for memory T cells, and thus MILs are rich in this cell type. Memory T cells have been shown to be long-lasting and particularly effective at destroying tumors.
Human clinical experience has demonstrated that MILs are associated with only mild side effects, as well as a complete absence of the cytokine release syndrome seen with many other cell-based therapies. This profile enables the use of MILs earlier in treatment.
There is no need to genetically modify MILs to make them tumor-specific—they already possess specificity for tumor antigens. Avoiding genetic manipulation reduces the cost and complexity of the manufacturing process.

MEET OUR TEAM

THE EXPERTS THAT DRIVE WINDMIL

CONTACT

Reach out to Windmil

  • 1812 Ashland Avenue, 1st Floor, Suite 100, Baltimore, MD 21205
  • 410-558-1906